Sodium Acetate → 9-Methoxy-nonanal

a 50-mL, one-necked, round-bottom flask equipped with a magnetic stirrer and stir bar was charged with 9-methoxy-nonanol (1.0 g, 5.9 mmol), dichloromethane (10 mL), molecular sieves (1.0 g, 3A), sodium acetate (0.1 g) at room temperature. The reaction mixture was stirred at room temperature under nitrogen for 5 minutes. The reaction mixture was charged with pyridinium dichromate (4.7 g, 12.5 mmol) and stirred overnight. The progress of reaction was monitored by TLC (Note 1). After completion of the reaction, the reaction mixture was filtered through a bed of silica gel (˜15 g). The filtrate was evaporated in vacuo to obtain a crude compound. This was purified by column chromatography using silica gel column (250-400 mesh, 40 g). A solvent gradient of ethyl acetate in hexane (10-50%) was used to elute the product from the column. All fractions containing the desired pure product were combined and concentrated in vacuo to give pure 9-methoxy-nonanal (lot D-1027-156, 553 mg, 54.4%). Completion of the reaction was monitored by thin layer chromatography (TLC) using a thin layer silica gel plate; eluent: 60% ethyl acetate in hexanes.

1. customa 50-mL, one-necked, round-bottom flask equipped with a magnetic stirrer
2. stirringThe reaction mixture was stirred at room temperature under nitrogen for 5 minutes
3. stirringstirred overnight
4. customThe progress of reaction
5. customAfter completion of the reaction
6. filtrationthe reaction mixture was filtered through a bed of silica gel (˜15 g)
7. customThe filtrate was evaporated in vacuo
8. customto obtain a crude compound
9. customThis was purified by column chromatography
10. washto elute the product from the column
11. additionAll fractions containing the desired pure product
12. concentrationconcentrated in vacuo

ORD record

ord-edb2da7ddc294bf6a64fd3a025292d3a

Source dataset

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08426445B2