2-Methyl-5-Nitroaniline → HCID 67494338, compound

Participants

Reaction Steps

To a suspension of the product of step 1 (10.2 g) in anhydrous dichloromethane (250 ml), a solution of 2-methyl-5-nitroaniline (15.2 g) and triethylamine (21 ml, excess allowed) in dichloromethane (60 ml) was added dropwise slowly in an ice-bath with the temperature no more than 5° C. After to addition, the reaction was carried out for 30 min in an ice-bath, and then at room temperature for 3 h. The solution became clear yellow solution. The completion of the reaction was indicated by TLC. After that, potassium carbonate solution (10%) was added, and then the solid was precipitated, and filtered out. The filter cake was washed with water, and dried to give a pale-yellow powdered solid.

Provenance & Evidence