反应详情

Cis/trans-Ethyl 4-(ethyloxy)cyclohexanecarboxylate (D2, 21 g, 105 mmol) was dissolved in MeOH-THF (100 mL-100 mL) and NaOH (5 eq., 0.5 mol, 40 mL, 12.5 N aqueous solution) was slowly added at room temperature. The mixture was stirred at room temperature overnight. The THF/MeOH was then evaporated and the crude was washed with Et2O. The aqueous phase was acidified and extracted with EtOAc (2×); organics were dried over Na2SO4, filtered and the solvent was evaporated to afford the title compound as a pale-yellow oil, 17.3 g, 96%.

1. customThe THF/MeOH was then evaporated
2. washthe crude was washed with Et2O
3. extractionextracted with EtOAc (2×)
4. dry with materialorganics were dried over Na2SO4
5. filtrationfiltered
6. customthe solvent was evaporated