Acetic Acid → HCID 178468170, compound

Participants

Reaction Steps

2-Amino-4-methylphenol (56.1 mg, 0.456 mmol) was dissolved in dichloromethane (3 mL) and 1-[trans-4-(ethyloxy)cyclohexyl]-4-piperidinone (D66, 103 mg, 0.456 mmol), polymer supported sodium cyanoborohydride (212 mg, 0.912 mmol, 4.3 mmol/g) and acetic acid (0.13 mL, 2.28 mmol) were all added at rt. The mixture was reacted at 100° C. in the microwave for 10 min. The mixture was then cooled to rt, filtered and concentrated by rotary evaporation to give 2-({1-[trans-4-(ethyloxy)cyclohexyl]-4-piperidinyl}amino)-4-methylphenol (D29, 215 mg, 92% yield) as a white solid.

Provenance & Evidence