HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-methyl-6-nitrophenol → 2-Amino-6-fluoro-4-methylphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-methyl-6-nitrophenol | HCID 22753815 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-6-fluoro-4-methylphenol | HCID 55282121 | 76% |
Reaction Steps
A solution of 2-fluoro-4-methyl-6-nitrophenol D41 (400 mg, 2.337 mmol) (D41) in ethanol (50 mL) was hydrogenated using a Pd/C cartridge in the H-cube™ hydrogenator at 1 mL/min and full hydrogen. Evaporation gave 2-fluoro-4-methyl-6-aminophenol (250 mg, 1.771 mmol, 76% yield) as a fawn solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426443B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f20c39b1e3274791808bdbd644c29743 |
| Source note | uspto-grants-2013_04 |