HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Difluoro-4-methyl-6-nitrophenol → 6-Amino-2,3-difluoro-4-methyl-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Difluoro-4-methyl-6-nitrophenol | HCID 59444160 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Amino-2,3-difluoro-4-methyl-phenol | HCID 59444170 | 99% |
Reaction Steps
A solution of 2,3-difluoro-4-methyl-6-nitrophenol (1.2 g, 6.35 mmol) (D44) in ethanol (120 mL) was hydrogenated using a 10% Pd/C cartridge in the H-cube™ hydrogenator at 1 mL/min and full hydrogen at 25° C. Evaporation gave 2,3-difluoro-4-methyl-6-aminophenol (1.0 g, 6.28 mmol, 99% yield) as a fawn solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426443B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ffcce64ba1a6474780945b0edde08465 |
| Source note | uspto-grants-2013_04 |