Hydrochloric Acid → HCID 44538949, compound

Participants

Reaction Steps

To {3-[2-({acetyl-[2-(4-fluoro-phenyl)-1,1-dimethyl-ethyl]-amino}-methyl)-4-bromo-phenoxy]-phenyl}-acetic acid methyl ester (0.094 g, 0.17 mmol) in THF (2 mL) was added 1N aqueous lithium hydroxide (2 mL), and the reaction was stirred at room temperature until no starting material was seen by analytical LCMS. The mixture was acidified with 1N aqueous HCl and extracted three times with EtOAc. The combined organic layers were dried and concentrated, and the residue was purified by preparative HPLC to give the title compound. M+H=529.

Provenance & Evidence