Methyl chloroformate → HCID 58288490, compound

HRID 1969025Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][NH:20][C@@H:21]([CH3:29])[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:6]=1.Cl[C:32]([O:34][CH3:35])=[O:33]>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][N:20]([C:32]([O:34][CH3:35])=[O:33])[C@@H:21]([CH3:29])[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:6]=1

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 58288487HCID 58288487, compound

Product 1

HCID 58288490HCID 58288490, compound

Procedure

Prepared according to the procedure described in Example 2, Step 4, using the following starting materials: (3-{4-bromo-2-[((S)-1-methyl-2-phenyl-ethylamino)-methyl]-phenoxy}-phenyl)-acetic acid methyl ester and methyl chloroformate.

Workup

customPrepared

Sources & evidence

ORD record: ord-71c62b4edaa44b6f8aefbade39332267
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08426449B2

Reaction notes

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