Ethanol → Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

HRID 1969028Notes

Reaction equation

HRID 1969028 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].S(=O)(=O)(O)O.[CH3:19][CH2:20]O>>[CH2:19]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=1)[CH3:20]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1605623-Hydroxy-4-methoxybenzeneacetic acid

Product 1

HCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Procedure

To 3-hydroxy-4-methoxyphenylacetic acid (5.0 g, 23.8 mmol) in EtOH (100 mL) was added sulfuric acid (1 mL), and the reaction was stirred overnight at room temperature. Once no starting material was seen by analytical TLC, the mixture was concentrated to give the title compound.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-2259174ec3c742c091d1ed0e2364bd63
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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