Acetyl chloride → (3-{2-[(Acetyl-ethyl-amino)-methyl]-4-bromo-phenoxy}-4-methoxy-phenyl)-acetic acid methyl ester

HRID 1969033Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:15]=2[CH2:21][NH:22][CH2:23][CH3:24])[CH:6]=1.[C:26](Cl)(=[O:28])[CH3:27]>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:15]=2[CH2:21][N:22]([C:26](=[O:28])[CH3:27])[CH2:23][CH3:24])[CH:6]=1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 58288534[3-(4-Bromo-2-ethylaminomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester

Product 1

HCID 58288484(3-{2-[(Acetyl-ethyl-amino)-methyl]-4-bromo-phenoxy}-4-methoxy-phenyl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 3, Step 3, using the following starting materials: [3-(4-bromo-2-ethylaminomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester and acetyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-df11b523b3e644d2b45a22a93eb5ac83
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08426449B2

Reaction notes

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