Methyl chloroformate → (3-{4-Bromo-2-[(ethyl-methoxycarbonyl-amino)-methyl]-phenoxy}-4-methoxy-phenyl)-acetic acid methyl ester

HRID 1969036Notes

Reaction equation

HRID 1969036 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:15]=2[CH2:21][NH:22][CH2:23][CH3:24])[CH:6]=1.Cl[C:27]([O:29][CH3:30])=[O:28]>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:15]=2[CH2:21][N:22]([CH2:23][CH3:24])[C:27]([O:29][CH3:30])=[O:28])[CH:6]=1

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 58288534[3-(4-Bromo-2-ethylaminomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester

Product 1

HCID 58288526(3-{4-Bromo-2-[(ethyl-methoxycarbonyl-amino)-methyl]-phenoxy}-4-methoxy-phenyl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 3 Step 3, using the following starting materials: [3-(4-bromo-2-ethylaminomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester and methyl chloroformate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-432a89ba8a904c77a00ff84a3c737449
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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