HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3'-Hydroxyphenylacetic acid | HCID 12122 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)benzaldehyde | HCID 2734904 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid | HCID 58237662 | — |
Reaction Steps
3-Hydroxyphenylacetic acid (1 g, 5.2 mmol), 2-fluoro-5-(trifluoromethyl)benzaldehyde (1 g, 6.6 mmol), and potassium carbonate (2.2 g, 15.6 mmol) were combined in THF (20 mL) and MeCN (20 mL), and the reaction was stirred at 70° C. for 3 days. After acidic workup, the crude material was purified by silica gel chromatography (20-100% EtOAc in hexanes) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426449B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e97552d0070f436d91ea5e6244cc6b01 |
| Source note | uspto-grants-2013_04 |