Ethanol → Ethyl (3-Hydroxyphenyl)acetate

HRID 1969045Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.[CH3:17][CH2:18]O>>[CH2:17]([O:10][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([OH:1])[CH:3]=1)[CH3:18]

Participants

Reactant 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 121223'-Hydroxyphenylacetic acid

Product 1

HCID 572437Ethyl (3-Hydroxyphenyl)acetate

Procedure

3-Hydroxyphenylacetic acid (5 g, 32.9 mmol) and sulfuric acid (1 mL) were stirred in EtOH (100 mL) at 70° C. for 1 hour. The mixture was worked-up to give the title compound.

Sources & evidence

ORD record: ord-a820c415e466423e90294552d4cb4289
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08426449B2

Reaction notes

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