4-Methanesulfonylbenzene-1-sulfonyl chloride → [3-(2-{[Ethyl-(4-methanesulfonyl-benzenesulfonyl)-amino]-methyl}-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

HRID 1969066Notes

Reaction equation

HRID 1969066 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:6]=1.[CH3:27][S:28]([C:31]1[CH:36]=[CH:35][C:34]([S:37](Cl)(=[O:39])=[O:38])=[CH:33][CH:32]=1)(=[O:30])=[O:29]>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([CH2:24][CH3:25])[S:37]([C:34]2[CH:33]=[CH:32][C:31]([S:28]([CH3:27])(=[O:30])=[O:29])=[CH:36][CH:35]=2)(=[O:39])=[O:38])[CH:6]=1

Participants

3

Reactant 2

HCID 27351824-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 58288538[3-(2-Ethylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58288469[3-(2-{[Ethyl-(4-methanesulfonyl-benzenesulfonyl)-amino]-methyl}-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 22, Step 1, using the following starting materials: [3-(2-ethylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester and 4-methylsulfonylbenzenesulfonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-63cd6da4df644e86bfe0ca675d3b031b
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

Loading…