2-Naphthalenesulfonyl chloride → [3-(2-{[Ethyl-(naphthalene-2-sulfonyl)-amino]-methyl}-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

HRID 1969068Notes

Reaction equation

HRID 1969068 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:6]=1.[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[S:37](Cl)(=[O:39])=[O:38]>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([CH2:24][CH3:25])[S:37]([C:28]2[CH:29]=[CH:30][C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH:27]=2)(=[O:39])=[O:38])[CH:6]=1

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 58288538[3-(2-Ethylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58288473[3-(2-{[Ethyl-(naphthalene-2-sulfonyl)-amino]-methyl}-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 22, Step 1, using the following starting materials: [3-(2-ethylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester and 2-naphthalenesulfonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-08c3a5d6dddd4ebf949d76ee3b7c2e8e
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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