Hydrochloric Acid → HCID 44539442, compound

Participants

Reaction Steps

To a solution of crude {3-[2-({ethyl-[4-(methyl-m-tolyl-amino)-benzenesulfonyl]-amino}-methyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid methyl ester (0.013 mmol) in THF was added aqueous lithium hydroxide (3 mL), and the reaction was stirred overnight at room temperature. The mixture was acidified with 1N aqueous HCl and extracted with EtOAc, and the combined organic layers were dried and concentrated. The residue was purified by preparative HPLC to give the title compound. M+H=613.

Provenance & Evidence