Acetyl chloride → (3-{2-[(Acetyl-benzyl-amino)-methyl]-4-trifluoromethyl-phenoxy}-4-methoxy-phenyl)-acetic acid ethyl ester

HRID 1969077Notes

Reaction equation

HRID 1969077 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH2:25][NH:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:7]=1)[CH3:2].[C:35](Cl)(=[O:37])[CH3:36]>>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][C:16]=2[CH2:25][N:26]([C:35](=[O:37])[CH3:36])[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 58288522{3-[2-(Benzylamino-methyl)-4-trifluoromethyl-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester

Product 1

HCID 58288468(3-{2-[(Acetyl-benzyl-amino)-methyl]-4-trifluoromethyl-phenoxy}-4-methoxy-phenyl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 3, Step 3, using the following starting materials: {3-[2-(benzylamino-methyl)-4-trifluoromethyl-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester and acetyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-571b237266d7489f913edd030af700eb
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

Loading…