反应详情

温度

35 °C

To a solution of tert-butyl {2-[(4-bromophenyl)(hydroxy)methyl]-4-chlorophenyl}carbamate (10 g, 25 mmol) in 100 ml CH2Cl2, was added MnO2 (10 g, 125 mmol) and the mixture was heated to 35° C. for 48 hours. Filtration and concentration gave tert-butyl [2-(4-bromobenzoyl)-4-chlorophenyl]carbamate as a yellow solid. 1HNMR: (400 MHz, CDCl3) δ 9.77 (s, 1H), 8.39 (d, J=8.8 Hz, 1H), 7.65 (d, J=8.4 Hz, 2H), 7.57 (d, J=8.4 Hz, 2H), 7.49 (dd, J=8.8, 2.0 Hz, 1H), 7.42 (d, J=2.4 Hz, 1H), 1.51 (s, 9H).

1. filtrationFiltration and concentration