HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromopyridine-2,3-diamine → 6-Bromoimidazo[1,2-a]pyridin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromopyridine-2,3-diamine | HCID 691156 | — |
| Reactant | Acetaldehyde, chloro-, hydrate | HCID 12227820 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-Bromoimidazo[1,2-a]pyridin-8-amine | HCID 17750394 | 93.6% |
Reaction Steps
2,3-diamino-5-bromopyridine (10.0 g, 45.86 mmol) was dissolved in 80 ml of IPA and then 50% wt chloroacetaldehyde/H2O (6.51 ml, 50.45 mmol) was added. The resulting mixture was heated at reflux for 24 hrs. The mixture was cooled down and then filtered. The cake was dried to afford 9.10 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426441B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-925180d0a90949ccb110155ab3ccb8b7 |
| Source note | uspto-grants-2013_04 |