HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-(6-Chloropyridine-3-carbonyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(6-Chloropyridine-3-carbonyl)morpholine | HCID 857499 | 97.1% |
Reaction Steps
To a solution of 6-chloro nicotinic acid (1.11 g, 7.04 mmol) in CH2Cl2 at 0 C was added EDCI (2.70 g, 14.08 mmol) and HOBt and then the resulting mixture was stirred for 30 minutes at 0 C. After that, morpholine (2.46 ml, 28.17 mmol) was added, the ice-bath removed and the reaction was done in 15 minutes. Water was added, the mixture was extracted with CH2Cl2, dried over MgSO4 and concentrated to afford 1.55 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426441B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-92f34981b2254afe8459f4b58b052c71 |
| Source note | uspto-grants-2013_04 |