Sodium Carbonate → HCID 57786721, compound

Participants

Reaction Steps

The mixture of 105 mg (0.493 mmol) of 6-Bromo-imidazo[1,2-a]pyridin-8-ylamine, 195 mg (0.591 mmol) of Pyrrolidine-1-carboxylic acid [2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-amide, 157 mg (1.48 mmol) of sodium carbonate, and 57 mg (0.049 mmol) of tetrakis(triphenylphosphine)palladium in 5 mL of 1,2-dimethoxyethane and 2.5 mL of water was heated at 110 C for 30 minutes using microwave. The mixture was partitioned between 50 mL of ethyl acetate and 10 mL of water. The organic layer was dried (MgSO4), and concentrated. Column chromatography (0->10% MeOH/CH2Cl2 in 20 minutes) gave 104 mg (0.310 mmol, 63%) of the title compound.

Provenance & Evidence