1,1,1,3,3,3-Hexafluoro-2-propanol → HCID 57786782, compound

Participants

Reaction Steps

A solution of methanesulfonic acid 1-benzhydryl-azetidin-3-yl ester (0.194 g, 0.61 mmol) in 2 mL of hexafluoroisopropanol in a sealed tube was stirred at 100° C. for 14 h, then concentrated. The residue was partitioned between 5 mL of ethyl acetate and 5 mL of a 10% NaOH solution. The organic layer was sequentially washed with 5 mL of water and 5 mL of a sat. aq. NaCl solution; dried over MgSO4, filtered and concentrated to an orange-yellow oil. Column chromatography (0-<20% EtOAc/hexanes) afforded 0.059 g (25%) of 1-benzhydryl-3-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-azetidine as a colorless oil.

Provenance & Evidence