HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1969129Generated: October 30, 2026
Sodium Carbonate → Methyl 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinate
https://huagongshe.com/reaction/1969129
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 2-chloropyridine-4-carboxylate | HCID 2736842 | — |
| Reactant | [4-(Benzyloxy)-3-cyanophenyl]boric acid | HCID 66995522 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinate | HCID 66995135 | — |
Reaction Steps
[4-(Benzyloxy)-3-cyanophenyl]boric acid and methyl 2-chloroisonicotinate were dissolved in a mixture liquid of toluene and an aqueous 2 M sodium carbonate solution, and in the presence of tetrakis(triphenylphosphine)palladium, the mixture was stirred under heating in an argon atmosphere at 100° C. to obtain methyl 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinate. F: 345.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08426453B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-093fc5152bd54a318c9fb14072a08c3b |
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| Source note | uspto-grants-2013_04 |
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