HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 66995417, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 2-chloropyridine-4-carboxylate | HCID 2736842 | — |
| Reactant | HCID 66995493 | HCID 66995493 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66995417 | HCID 66995417 | — |
Reaction Steps
(3-Cyano-4-benzyloxy-5-fluorophenyl)boronic acid and methyl 2-chloroisonicotinate were dissolved in a mixed solution of toluene and a 2M aqueous sodium carbonate solution, followed by heating under reflux for 3 hours in the presence of tetrakis(triphenylphosphine)palladium to obtain methyl 2-(3-cyano-4-benzyloxy-5-fluorophenyl)isonicotinate. F: 363.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426453B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-77c4069eedbf4119a761467e2ef3aa5a |
| Source note | uspto-grants-2013_04 |