HCID 66995417, compound → HCID 136368380, compound

HRID 1969137Notes

Reaction equation

HRID 1969137 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][N:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH:6]=[C:7]([F:17])[C:8]=1[O:9]CC1C=CC=CC=1)#[N:2]>CO.C1COCC1.[C].[Pd]>[C:1]([C:3]1[CH:4]=[C:5]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][N:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH:6]=[C:7]([F:17])[C:8]=1[OH:9])#[N:2]

Participants

4

Reactant 1

HCID 66995417HCID 66995417, compound

Product 1

HCID 136368380HCID 136368380, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Methyl 2-(3-cyano-4-benzyloxy-5-fluorophenyl)isonicotinate is stirred at room temperature in methanol-THF (1:1) under a hydrogen atmosphere at normal pressure in the presence of palladium-carbon to obtain methyl 2-(3-cyano-5-fluoro-4-hydroxyphenyl)isonicotinate. FN: 271.

Sources & evidence

ORD record
ord-e8b5d7721ebf4e1aa90ebbd167bf322a
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Reaction notes

Loading…