HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1969145Generated: October 31, 2026
Sodium Azide → Methyl 2-(4-azido-3-cyanophenyl)isonicotinate
https://huagongshe.com/reaction/1969145
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Methyl 2-(3-cyano-4-fluorophenyl)isonicotinate | HCID 66995083 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-(4-azido-3-cyanophenyl)isonicotinate | HCID 86626138 | — |
Reaction Steps
Methyl 2-(3-cyano-4-fluorophenyl)isonicotinate and sodium azide were dissolved in a DMF solution, followed by stirring at 50° C. for 4 hours to obtain methyl 2-(4-azido-3-cyanophenyl)isonicotinate. NMRC: 7.38 (1H, d), 7.84 (1H, dd), 8.46 (1H, d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426453B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-a53bb41791f7486fbb57420c248c1b94 |
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| Source note | uspto-grants-2013_04 |
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