Boron tribromide → HCID 136407406, compound

HRID 1969149Notes

Reaction equation

HRID 1969149 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:11]2[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[O:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9]C)#[N:2].BrB(Br)Br>ClCCl>[C:1]([C:3]1[CH:4]=[C:5]([C:11]2[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[O:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[OH:9])#[N:2]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 66995258HCID 66995258, compound

Product 1

HCID 136407406HCID 136407406, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl 3-(3-cyano-4-methoxyphenyl)-5-isoxazolecarboxylate and tribromoborane were dissolved in a dichloromethane solution, followed by stirring for 2 hours under ice-cooling. Further, the mixture was stirred at 40° C. for 30 minutes to obtain ethyl 3-(3-cyano-4-hydroxyphenyl)-5-isoxazolecarboxylate. APN: 257.

Workup

  1. temperaturecooling
  2. stirringFurther, the mixture was stirred at 40° C. for 30 minutes

Sources & evidence

ORD record
ord-fd38cd944c864f81be5d75c280d212ff
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Reaction notes

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