Boron tribromide → HCID 136407401, compound

HRID 1969154Notes

Reaction equation

HRID 1969154 reaction equation
B(Br)(Br)Br.[C:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:19]=[C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[S:17][N:16]=2)[CH:10]=[CH:11][C:12]=1[O:13]C)#[N:6]>ClCCl>[C:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:19]=[C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[S:17][N:16]=2)[CH:10]=[CH:11][C:12]=1[OH:13])#[N:6]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 66995397HCID 66995397, compound

Product 1

HCID 136407401HCID 136407401, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Under ice-cooling, boron tribromide was added to a dichloromethane solution of ethyl 3-(3-cyano-4-methoxyphenyl)isothiazole-5-carboxylate, followed by stirring for 1 hour and then stirring at 40° C. for 3 hours to obtain ethyl 3-(3-cyano-4-hydroxyphenyl)isothiazole-5-carboxylate. AP: 297.

Workup

  1. temperatureUnder ice-cooling
  2. stirringstirring at 40° C. for 3 hours

Sources & evidence

ORD record
ord-7820401a607c413f829c7af1c90734a8
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Reaction notes

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