Hexylamine → HCID 17757374, compound

HRID 1969157Notes

Reaction equation

HRID 1969157 reaction equation
[C:1]([CH2:4][CH2:5][C:6]([NH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=O)=[C:11]([OH:19])[CH:10]=1)=[O:7])([OH:3])=[O:2].[CH2:20]([NH2:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>CO>[CH2:20]([NH:26][C:13](=[O:15])[C:12]1[CH:17]=[CH:18][C:9]([NH:8][C:6](=[O:7])[CH2:5][CH2:4][C:1]([OH:3])=[O:2])=[CH:10][C:11]=1[OH:19])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

4

Reactant 2

HCID 8102HexylamineHCID 25117631HCID 25117631, compound

Product 1

HCID 17757374HCID 17757374, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-(3-carboxy-propionylamino)-2-hydroxybenzoate from Example 2 (1 g) is dissolved in 15 mL of methanol. n-Hexylamine (5 mL) is added to this solution, and the reaction mixture is brought to mild reflux for 2 days. Solvents are removed under vacuum and residue acidified using 1 N HCl. N-n-hexyl 4-(3-carboxy-propionylamino)-2-hydroxybenzamide precipitate is collected, washed with water, and dried.

Workup

  1. temperatureto mild reflux for 2 days
  2. customSolvents are removed under vacuum and residue
  3. customN-n-hexyl 4-(3-carboxy-propionylamino)-2-hydroxybenzamide precipitate is collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-e917d05e76dd4561ae679bd01318c810
Source dataset
uspto-grants-2013_04
Patent number
US08426466B2

Reaction notes

Loading…