HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-chloro-4-iodo-N-methylpyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (6-chloro-4-iodopyridin-3-yl)(methyl)carbamate | HCID 57443399 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-chloro-4-iodo-N-methylpyridin-3-amine | HCID 57443400 | 97.7% |
Reaction Steps
To the solution of tert-butyl (6-chloro-4-iodopyridin-3-yl)(methyl)carbamate (62.5 g, 0.172 mol) in 500 mL of anhydrous DCM was added 180 mL of TFA. Then the solution was stirred at room temperature for 4 hrs. Concentrated to remove the solvent, and purified by flash chromatography to afford 45.1 g 6-chloro-4-iodo-N-methylpyridin-3-amine as a yellow solid (Yield: 97.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426450B1 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5b59f63fff664a2eb39c6270c741fce4 |
| Source note | uspto-grants-2013_04 |