Ethyl (4-mercapto-2-methylphenoxy)acetate → HCID 57791904, compound

HRID 1969201Notes

Reaction equation

HRID 1969201 reaction equation
Br[C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:5]=[C:4]([Br:19])[CH:3]=1.[CH2:20]([O:22][C:23](=[O:34])[CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([SH:32])=[CH:28][C:27]=1[CH3:33])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:34])[CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([S:32][C:2]2[CH:7]=[C:6]([O:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[CH:5]=[C:4]([Br:19])[CH:3]=2)=[CH:28][C:27]=1[CH3:33])[CH3:21]

Participants

3

Reactant 2

HCID 16641178Ethyl (4-mercapto-2-methylphenoxy)acetateHCID 671714461,3-Dibromo-5-[3-(trifluoromethyl)phenoxy]benzene

Product 1

HCID 57791904HCID 57791904, compound

Procedure

1,3-Dibromo-5-(3-trifluoromethyl-phenoxy)-benzene (1.35 g; 3.4 mmol) and (4-Mercapto-2-methyl-phenoxy)-acetic acid ethyl ester (0.7 g; 3.1 mmol) was condensed to give the title product applying the procedure described for {4-[3-Bromo-5-cyclopentylmethoxy-phenylsulfanyl)-2-methyl-phenoxy]-acetic acid ethyl ester. The crude product was purified by preparative HPLC (Method A) followed by flash chromatography (dichloromethane:heptane 3:7). Yield 0.5 g. HPLC-MS: m/z: 541.3 (M)+; Rt: 3.03 min.

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-4fbf260643974d06ac634452f447be48
Source dataset
uspto-grants-2013_04
Patent number
US08426473B2

Reaction notes

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