HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2,5-Dimethyl-4-mercaptophenoxy-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Methyl Acetate | HCID 6584 | — |
| Reactant | Ethyl [4-(chlorosulfonyl)-2,5-dimethylphenoxy]acetate | HCID 20768123 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,5-Dimethyl-4-mercaptophenoxy-acetic acid ethyl ester | HCID 20768107 | — |
Reaction Steps
(4-Mercapto-2,5-dimethyl-phenoxy)-acetic acid ethyl ester was prepared as described for 2,6-difluoro-4-mercapto-phenoxy)acetic acid methyl ester (compound 21) in Eur. J. Med. Chem., 1995, 30, 403 (Kawashima, M. S.) except that (4-chlorosulfonyl-2,5-dimethyl-phenoxy)acetic acid ethyl ester was reduced with 4 eq. of zn (dust) in a mixture of konc. sulfuric acid and ethanol at 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426473B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-9e0b83e47d3047aebc1254d33dd27537 |
| Source note | uspto-grants-2013_04 |