HCID 86651443, compound → HCID 58165899, compound

Participants

Reaction Steps

A solution of 1-(2,3-dideoxy-5-O-trityl-β-D-ribofuranosyl)-4-(1-propynyl)pyrrole-2-carbaldehyde (82 mg, 171 μmol) dissolved in 80% acetic acid (10 ml) was stirred at room temperature for 3 hours, and then at 50° C. for 2 hours. The reaction solution was concentrated under reduced pressure and repeated co-evaporation with water. The resulting crude product was purified by column chromatography on silica gel (0-1% CH3OH in CH2Cl2) and RP-HPLC (35-80% CH3CN in water, 12 min) to give the title product (31 mg, 78%).

Provenance & Evidence