HCID 86647901, compound → HCID 68453416, compound

Participants

Reaction Steps

A stirred solution of (E)-Methyl 4-(4-amino-2-fluorobut-2-enyloxy)benzoate hydrochloride (0.050 g, 0.18 mmol) in ethereal HCl solution (1 M; 3 mL) was stirred at reflux for 20 hours. The reaction mixture was allowed to cool to RT and the volatiles were removed under reduced pressure to afford the title compound (0.040 g, 98%) as a fine white powder; m.p.=256-257° C.; 1H-NMR (200 MHz, D2O): δppm: 3.77 (2H, d, J 8.4 Hz), 4.91 (2H, d, J 18.8 Hz), 5.65 (1H, dt, J 18.6, 8.0 Hz), 7.08 (2H, d, J 8.4 Hz), 8.00 (2H, d, J 8.4 Hz).

Provenance & Evidence