HCID 726575, compound → HCID 59588965, compound

HRID 1969329Notes

Reaction equation

HRID 1969329 reaction equation
Br[CH2:2]/[C:3](/[F:15])=[C:4](\[CH3:14])/[CH2:5][NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10].[CH:16]1([NH:22][C:23](=[O:31])[C:24]2[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([NH:22][C:23]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH2:2]/[C:3](/[F:15])=[C:4](\[CH3:14])/[CH2:5][NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:26][CH:25]=2)=[O:31])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 726575HCID 726575, compoundHCID 86647902HCID 86647902, compound

Product 1

HCID 59588965HCID 59588965, compound

Procedure

This compound was synthesized from tert-butyl [(2Z)-4-bromo-3-fluoro-2-methylbut-2-en-1-yl]carbamate and N-cyclohexyl-4-hydroxybenzamide following procedure F and was obtained as a colorless solid; 1H-NMR (400 MHz, CDCl3): δppm: 1.14-1.30 (3H, m), 1.35-1.49 (2H, m), 1.44 (9H, s), 1.60-1.70 (1H, m), 1.70-1.79 (2H, m), 1.76 (3H, d, J 3.2 Hz), 1.98-2.04 (2H, m), 3.90 (2H, d, J 5.3 Hz), 3.96 (1H, m), 4.59 (1H, br s), 4.63 (2H, d, J 21.2 Hz), 5.86 (1H, d, J 7.9 Hz), 6.93 (2H, d, J 8.7 Hz), 7.71 (2H, d, J 8.7 Hz).

Workup

  1. customwas obtained as a colorless solid

Sources & evidence

ORD record
ord-5cb04e290a6d4b51a719c7e286bbc043
Source dataset
uspto-grants-2013_04
Patent number
US08426587B2

Reaction notes

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