HuagongsheHuagongshe Chemistry Print Report · For research reference only
Doxazosin → Doxazosin Monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Doxazosin | HCID 3157 | — |
| Reactant | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| Reactant | N-1,4-Benzodioxane-2-carbonyl piperazine | HCID 2735449 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | Doxazosin Monohydrochloride | HCID 11591230 | — |
Reaction Steps
Organic Preparations and Procedures International (2003); 35; 603-608 describes the procedure for synthesizing doxazosin by treating (2,3-dihydrobenzo[b][1,4]dioxin-2-yl) (piperazin-1-yl)methanone with 2-chloro-6,7-dimethoxy quinazolin-4-amine in presence of n-butanol to obtain doxazosin hydrochloride; which on further treatment with aqueous ammonia solution yields doxazosin base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426590B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c9baeff231494017b337b490b2b22b32 |
| Source note | uspto-grants-2013_04 |