Hydrochloric Acid → HCID 67215759, compound

Participants

Reaction Steps

To a solution of ethyl 5-fluoro-1-[4-[4-formyl-1H-pyrazol-1-yl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate (0.100 g, 0.238 mmol) in 2 mL of dichloromethane was added trimethyl(trifluoromethyl)silane (0.045 g, 0.25 mmol) and cesium fluoride (3.6 mg, 0.024 mmol). After 3 hours, 4 N HCl (0.36 mL, 1.4 mmol) was added. After 1 hour, the reaction mixture was diluted with an additional 20 mL dichloromethane and washed with water and brine. The organic extracts were dried, filtered and concentrated in vacuo to provide the title compound (crude) which gave a mass ion (ES+) of 489.9 for M+H+. This compound could be further hydrolyzed to the corresponding carboxylic acid, as described in Example 1.

Provenance & Evidence