Ethyl pyruvate → HCID 66909220, compound

Participants

Reaction Steps

Add 3-(trifluoromethoxy)benzaldehyde (10.0 g, 52.6 mmol) to a solution of 4-aminobenzonitrile (18.6 g, 157.8 mmol) in glacial acetic acid (53 mL). Stir at ambient temperature for 20 min. and a precipitate forms. Add ethyl pyruvate (5.8 mL, 52.6 mmol). Stir at ambient temperature for 18 hours. Filter the precipitate and wash with glacial acetic acid and then with 1:1 hexanes-diethyl ether to afford the titled compound (12.8 g, 53%). LC-MS ESI m/z: 461 (M+H)+, 459 (M−1)−, Tr=3.05 min., method 2.

Provenance & Evidence