HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(6-Bromopyridin-2-yl)propan-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(2-(6-bromopyridin-2-yl)propan-2-yl)acetamide | HCID 86004847 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-(6-Bromopyridin-2-yl)propan-2-amine | HCID 58129459 | 81.4% |
Reaction Steps
Combine N-[1-(6-bromo-pyridin-2-yl)-1-methyl-ethyl]-acetamide (3.3 g, 12.8 mmol) with 5N HCl (200 mL) and reflux overnight. Cool, add ice and neutralize with 1:1 ice: 50% NaOH until the mixture turns cloudy. Extract with dichloromethane, dry (Na2SO4), and evaporate to give 1-(6-bromo-pyridin-2-yl)-1-methyl-ethylamine (2.24 g, 81%). MS (m/z) 215 and 217 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426448B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6560b6c1671b4b97af9f9aad0f845e13 |
| Source note | uspto-grants-2013_04 |