p-Toluenesulfonate → HCID 86650671, compound

Participants

Reaction Steps

Tosylate Salt formation: Add p-toluenesulonic acid monohydrate (28.2 mg, 0.146 mmol) to a solution of 4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile (80 mg, 0.146 mmol) in dichloromethane. Evaporate to give a quantitative mass balance of 4-[(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-2-oxo-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-1-yl]-benzonitrile tosylate as a foam. LC-MS ESI m/z: 548.6 (M+H)+, 571.6 (M+Na)+, Tr=2.34 min., method 2.

Provenance & Evidence