反应详情

4.78 g (purity 77%, 10.882 mmol) of 2-amino-4-(2-bromo-1,3-thiazol-4-yl)-6-sulfanylpyridine-3,5-dicarbonitrile were initially charged in 30 ml of DMF, 2.923 g (11.971 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 2.742 g (32.647 mmol) of sodium bicarbonate were added and the mixture was stirred at room temperature overnight. The reaction mixture was added to water, and the precipitated solid was filtered off with suction, washed with water and dried under high vacuum. The contaminated product was applied to silica gel and purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 2:1). The product-containing fractions were concentrated, the residue was triturated with dichloromethane and the solid was filtered off, washed with dichloromethane and dried under high vacuum. This gave 1.1 g of the target compound in a purity of 91% (yield: 17% of theory).

1. filtrationthe precipitated solid was filtered off with suction
2. washwashed with water
3. customdried under high vacuum
4. custompurified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 2:1)
5. concentrationThe product-containing fractions were concentrated
6. customthe residue was triturated with dichloromethane
7. filtrationthe solid was filtered off
8. washwashed with dichloromethane
9. customdried under high vacuum