Sodium Bicarbonate → HCID 44229575, compound

Participants

Reaction Steps

90 mg (about 0.298 mmol) of 2-amino-6-sulfanyl-4-(1,3-thiazol-4-yl)pyridine-3,5-dicarbonitrile, together with 93 mg (0.382 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 88 mg (1.041 mmol) of sodium bicarbonate, were stirred in 20 ml of DMF at room temperature for 2 h. The reaction mixture was purified twice by preparative HPLC (acetonitrile/water: 10:90→95:5, 0.1% TFA added). This gave 36 mg (22% of theory) of the target compound.

Provenance & Evidence