Diisopropylethylamine → HCID 67346958, compound

Participants

Reaction Steps

80 mg (0.170 mmol) of 2-chloro-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile, together with 37 mg (0.340 mmol) of azetidin-3-ol hydrochloride and 44 mg (0.340 mmol) of N-ethyl-N-(1-methylethyl)propan-2-amine, were dissolved in 1 ml of THF. The mixture was stirred at room temperature for two hours, and the product was then purified by preparative HPLC (acetonitrile/water: 10:90→95:5, 0.1% TFA added). This gave 40 mg (46% of theory) of the target compound.

Provenance & Evidence