Propylene Oxide → HCID 66897662, compound

Participants

Reaction Steps

10 mg (0.022 mmol) of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(1H-pyrazol-3-yl)pyridine-3,5-dicarbonitrile were dissolved in 1 ml of 2-methyloxirane, and a spatula tip of cesium carbonate was added. The reaction mixture was stirred at room temperature overnight, concentrated, taken up in a little methanol and purified by preparative HPLC (acetonitrile/water: 10:90→95:5, 0.1% TFA added). This gave 10 mg (86% of theory) of the target compound.

Provenance & Evidence