Sodium Bicarbonate → HCID 67348744, compound

Participants

Reaction Steps

70 mg (0.271 mmol) of 2-amino-6-sulfanyl-4-thiophen-2-ylpyridine-3,5-dicarbonitrile, together with 79 mg (0.325 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 91 mg (1.084 mmol) of sodium bicarbonate, were stirred in 2 ml DMF at room temperature overnight. The reaction mixture was filtered and the filtrate was purified by preparative HPLC (Chromasil, water/acetonitrile—without acid). This gave 94 mg (71% of theory) of the target compound.

Provenance & Evidence