Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Iodo-1-propanol | HCID 69390 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 178510466 | HCID 178510466 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 44229842 | HCID 44229842 | — |
Reaction Steps
50 mg (0.092 mmol) of the compound from Example 5 were dissolved in 0.8 ml of DMF, 15 mg (0.101 mmol) of DBU and 21 mg (0.111 mmol) of 3-iodopropanol were added and the mixture was stirred at 120° C. overnight. A little water and ethyl acetate were added to the mixture, and the two phases formed were separated. The aqueous phase was extracted twice with ethyl acetate. The combined organic phases were concentrated on a rotary evaporator and the residue was purified by thick-layer chromatography (toluene:acetonitrile=3:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08426602B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-642226e825314f368a65e4e4a49e15bc |
|---|
| Source note | uspto-grants-2013_04 |
|---|
