Ethanolamine → 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-6-[(2-hydroxyethyl)amino]-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile

Participants

Reaction Steps

100 mg (purity 91%, 0.186 mmol) of 2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile were initially charged in 5 ml of THF, 0.023 ml (0.373 mmol) of 2-aminoethanol was added and the mixture was stirred at room temperature for 30 min. The product was then isolated by preparative HPLC. This gave 64 mg (67% of theory) of the target compound.

Provenance & Evidence