HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1969496Generated: October 31, 2026
2-(Methylamino)ethanol → HCID 67349839, compound
https://huagongshe.com/reaction/1969496
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | 2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(2-iodo-1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile | HCID 66896756 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 67349839 | HCID 67349839 | — |
Reaction Steps
130 mg (0.219 mmol) of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(2-iodo-1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile were initially charged in 2.5 ml of acetone, 0.885 ml (10.963 mmol) of 2-(methylamino)ethanol was added and the mixture was stirred at 80° C. overnight. The reaction mixture was concentrated and the product was isolated by preparative HPLC. This gave 74 mg (63% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08426602B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-d9d44d24400b4e1aa21b00a29bc4eeaf |
|---|
| Source note | uspto-grants-2013_04 |
|---|
