Ethanolamine → HCID 86657024, compound

HRID 1969497Notes

Reaction equation

HRID 1969497 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[S:14][C:13](I)=[N:12][CH:11]=2)[C:5]([C:16]#[N:17])=[C:4]([S:18][CH2:19][C:20]2[N:21]=[C:22]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[S:23][CH:24]=2)[N:3]=1.[NH2:32][CH2:33][CH2:34][OH:35]>CC(C)=O>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[S:14][C:13]([NH:32][CH2:33][CH2:34][OH:35])=[N:12][CH:11]=2)[C:5]([C:16]#[N:17])=[C:4]([S:18][CH2:19][C:20]2[N:21]=[C:22]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[S:23][CH:24]=2)[N:3]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 668967562-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(2-iodo-1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile

Product 1

HCID 86657024HCID 86657024, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

94 mg (0.159 mmol) of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(2-iodo-1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile were initially charged in 2.5 ml of acetone, 0.479 ml (7.927 mmol) of 2-aminoethanol was added

Sources & evidence

ORD record
ord-6a3182c1d3bd4914bb175727372adcf6
Source dataset
uspto-grants-2013_04
Patent number
US08426602B2

Reaction notes

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