Hydrochloric Acid → HCID 67216860, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2R,4S)-tert-butyl 4-(cyclopropanesulfonamido)-2-ethylpyrrolidine-1-carboxylate (0.95 g, 2.98 mmol, Preparation #15) in 1,4-dioxane (7.5 mL) was added HCl (4 N in 1,4-dioxane, 7.46 mL, 29.8 mmol). The reaction mixture was heated to about 60° C. After about 4 h, the reaction mixture was cooled to ambient temperature and concd in vacuo to provide crude N-((3S,5R)-5-ethylpyrrolidin-3-yl)cyclopropanesulfonamide hydrochloride (0.38 g, 50%) as a brown residue: LC/MS (Table 1, Method a) Rt=0.63 min; MS m/z: 219 (M+H)+.

Provenance & Evidence